Any additional coax loss will cost you something in terms of SNR for the more distant signals. Some of that depends on the quality of the LNA, so it’s hard to quantify how much you’ll lose.
If you want to eliminate coax losses as much as possible (without costly low-loss coax), put the receiver as close to the antenna as possible. I used a 32’ active USB extender cable and put my FlightAware Pro+ in the PVC antenna mast (sealed from the weather), so it’s just a couple of feet from the antenna – pretty much eliminates any coax loss. And my PiAware hangs on the wall of my ham shack at the other end of the 32’ extender.
Typically, even a passive USB extension cable will work well out to 20’ – and active USB extenders can be as long as 85’ (or more with a few tricks).
The downside to this is if you’re powering your LNA through the coax, you’ll have to find another way to feed it power. But the improved performance might be worth the effort.