Looking for a particular N3N-3

Education needed first:
Does a serial number ever change on a plane?
What does a “S” mean at the end of a registration number? The particular plane I’m looking for, per the FAA data, went from “N” followed by five numbers to a “N” followed by four numbers & ending with a “S”

Thank you in advance,

Do you mean serial number or tail/registration number? Tail numbers do change.

There’s no particular meaning to N-numbers (some are reserved for special uses, but that’s about all). There are a variety of possible formats. See https://www.faa.gov/licenses_certificates/aircraft_certification/aircraft_registry/forming_nnumber/